BIOL - Biology (BIOL)

Elementary statistical methods as applied to experimental biology. Topics include hypotheses testing, probability and chi square, linear regression and correlation, analyses of variance, nonparametric statistics and bioassay. Introduction to use of computers in analysis of biological data.

This introductory course provides an overview of the structure and function of the human nervous system. Emphasis is placed on understanding the cellular and molecular mechanisms underlying neural transmission, connectivity, integration of the sensory motor systems, cognitive functions and behavior.

Basic techniques used in recombinant DNA studies. Hands on experience with DNA isolation, hybrid plasmid production, restriction mapping and clone selection and characterization. Lecture will focus on theory and applications of recombinant DNA technology, including: vector design, PCR strategies, bioinformatics and DNA structure. Prerequisite: Genetics, Microbiology, Molecular Biology or Biochemistry. Prerequisite: Genetics, Microbiology or Biochemistry.

Study of structure and function of macromolecules. Prokaryotic and eukaryotic genome. Bacterial and bacteriophage genetics, mutation and gene expression. Genetic code, transcription, translation and the regulatory systems. Replication of viruses, genetic programming and biotechnology. Review of research papers and discussion of current topics. Prerequisite: Genetics or Biochemistry.

Synthesis and degradation of organic molecules in living systems, especially Man. Dietary, medical and genetic aspects of metabolism. Integration and regulation of pathways. Includes metabolic activities restricted to plants and microorganisms; representative antibiotics, toxins and drugs. Lecture only.

Principles of recognition, memory and specificity. Structural basis of antigenicity. Development of the immune system. Structure function and genetics of immunoglobulins, gammopathies and monoclonal antibodies. T-cell receptors and MHC antigens. Activation of lymphoid cells, tolerance, autoimmunity and regulation of the immune system. Complement system, aspects of clinical and diagnostic immunology, tissue typing and immunogenetics. A term paper is required.

Laboratory exercises designed to illustrate the immunological principles of recognition and specificity; in vitro and in vivo antigen-antibody reactions; identification and quantitation of immunoglobulins; tests to illustrate the principles of immunochemistry and immunopathology; cell culture study; hybridoma technique and monoclonal antibodies. Pre- or corequisite: BIOL 6242.

Role of hormones in coordinating homeostasis. Emphasis on neuroendocrinology, including functional neuroanatomy and neuro-chemistry. Study of the mechanism of action of hormones at the cellular and molecular levels. Review and analysis of current literature.

A comprehensive coverage of the physiology of cells, organs and organ systems with emphasis on the underlying biophysical and biochemical principles of function. Organ systems including nerve, muscle, cardiovascular, respiratory and renal are examined from the standpoint of their regulation and role in maintenance of homeostasis.

Discussion and practical application of the in vitro cultivation of animal cells including both general and specific techniques for obtaining, growing and maintenance of clonal cultures.

The participants in this course will become acquainted with basic concepts and techniques commonly used in Neuroscience to study the organization of neurons, their signaling pathways, and the mechanisms of synaptic transmission, in order to better understand the workings of the human brain.

This course brings together and puts into perspective a large body of knowledge about cancer, cancer research and cancer treatment. Specifically, this course will first explore microevolutionary processes to illustrate the nature of cancer and the natural history of the disease from a cellular standpoint. The molecular genetics of cancer will then be dissected to understand how abnormalities in any of the different intracellular signaling pathways of the system can lead to development of cancer. This course will also include a discussion of various cancer treatment approaches to illustrate how basic research translates to clinical aspects of cancer treatment.

Basic principles of the virus-host cell relationship presented by lectures and student discussion of recent publications. Topics include mechanisms of viral replication, viral-mediated genetic transfer, viral-induced host changes, including neoplasia and immunologic procedures fundamental to virology.

The normal life functions of microorganisms. The metabolism of E. coli, anaerobes, sulfur bacteria and photosynthetic bacteria as well as one-celled eukaryotes. Emphasis on general principles of physiology and the diversity of microbial solutions to physiological stresses. Includes lectures, text and reading, and discussion of original literature. Offered in alternate years.

Practical exercises, both bench methods and computational biology, addressing current techniques for measuring growth and physiology in a variety of microorganisms;  use of molecular databases to probe proteomics, metabolimics and other physiological processes.

Examination of the mechanisms of genetic recombination in microorganisms. Genetic changes in microorganisms and the resulting alterations in their biochemical and physiological features.

Students will gain an understanding of (1) the physical design of the compound light microscope and its relationship to image formation; (2) the physics of image formation; and (3) selected biological microscopic imaging techniques. Students will gain mastery of (1) the hands-on use of the compound light microscope, (2) basic sample preparation, (3) quantitative image analysis, and (4) the production of publication-quality images. Students will gain experience in the use of specific biological imaging techniques including wide-field fluorescence and confocal imaging, time-lapse imaging, and three-dimensional volume reconstruction. Three-hour lecture/lab.

Course brings together and puts into perspective a large body of knowledge about intracellular and intercellular signaling systems as well as cell-cell communication. Explores the molecular and cellular pathways, the components of these pathways, as well as the regulation of these pathways in cellular homeostasis. Current findings from the scientific literature are emphasized. Prerequisite: Cell Biology or Biochemistry.

This course is designed to introduce future scientists to topics in research ethics. Emphasis on foundational principles underlying scientific integrity and their application to a range of issues, including data management, animal and human subjects, collaboration, mentoring, peer review, and the ethical implications in different forms of scientific research.

Principles of toxicology; testing procedures used in toxicology studies, including carcinogenesis, mutagenesis, teratogenesis and immunotoxicology; studies of individual target organs such as the liver and kidney and systems such as cardiovascular, respiratory, nervous and reproductive; studies of risk assessment of toxic substances, such as food additives and pesticides. Prerequisite: Vertebrate Physiology.

Individualized study of a specific topic in molecular biology to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Individualized study of a specific topic in immunology to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Individualized study of a specific topic in genetics to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Individualized study of a specific topic in endocrinology to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Selection, genetic engineering and utilization of microorganisms in the production of food and drink, pharmaceuticals, chemicals and in agriculture. Emphasis on current techniques used in industry, and the principles and rationale guiding new developments that may become industrial processes of the future. Offered in alternate years. Prerequisites: Microbiology and Biochemistry or Metabolic Pathways.

Individualized study of a specific topic in microbiology to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Individualized study of a specific topic in neuroscience to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Individualized study of a specific topic in toxicology to be arranged between instructor and student. Student will research topic and develop a library research paper analyzing current research on the topic. It is required that an oral presentation of the paper will be given during scheduled seminar (BIOL 8202) the following semester.

Students are required to attend seminar for a minimum of two semesters and to present their thesis research during this period. Students register for BIOL 8201 in their first year and for BIOL 8202 in the semester that they intend to present their research. Those pursuing the non-thesis option also register for a Selected Topics course (1 credit) usually in the semester before they intend to present their library thesis.

Students are required to attend seminar for a minimum of two semesters and to present their thesis research during this period. Students register for BIOL 8201 in their first year and for BIOL 8202 in the semester that they intend to present their research. Those pursuing the non-thesis option also register for a Selected Topics course (1 credit) usually in the semester before they intend to present their library thesis.

Credit given at completion of project.

Credit given at completion of project.

Credit given at completion of project.

Credit given at completion of project.

Credit given at completion of project.

Subject and hours to be arranged. Credit for this course may be obtained only once.

Subject and hours to be arranged. Credit for this course may be obtained only once.

Subject and hours to be arranged. Credit for this course may be obtained only once.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Mandatory for all students. Students are required to attend seminar for a minimum of eight semesters. All students are required to present at least one seminar during this period. Students must register for this course in the semester they present a seminar based on their dissertation research.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.

Credits given at completion of dissertation.